The effects of cancer progression on the viscoelasticity of ovarian cell cytoskeleton structures.

@article{Ketene2012TheEO,
  title={The effects of cancer progression on the viscoelasticity of ovarian cell cytoskeleton structures.},
  author={Alperen N Ketene and Eva M. Schmelz and Paul C. Roberts and Masoud Agah},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2012},
  volume={8 1},
  pages={93-102}
}
UNLABELLED Alterations in the biomechanical properties and cytoskeletal organization of cancer cells in addition to genetic changes have been correlated with their aggressive phenotype. In this study, we investigated changes in the viscoelasticity of mouse ovarian surface epithelial (MOSE) cells, a mouse model for progressive ovarian cancer. We demonstrate that the elasticity of late-stage MOSE cells (0.549 ± 0.281 kPa) were significantly less than that of their early-stage counterparts (1.097… CONTINUE READING

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