The effects of caffeine on tension development and intracellular calcium transients in rat ventricular muscle.

@article{Konishi1984TheEO,
  title={The effects of caffeine on tension development and intracellular calcium transients in rat ventricular muscle.},
  author={Masato Konishi and Satoshi Kurihara and Toki Sakai},
  journal={The Journal of physiology},
  year={1984},
  volume={355},
  pages={605-18}
}
The effects of caffeine on tension and intracellular [Ca2+] were investigated in rat ventricular muscle using the Ca2+-sensitive photoprotein, aequorin. Contracture was induced by rapid application of 0.5-10 mM-caffeine solution at 20 degrees C. In normal Tyrode solution at 8 degrees C, or in Na+-deficient solution in which Na+ was isotonically replaced by sucrose, peak tension of caffeine contracture was potentiated and relaxation was prolonged. Caffeine contracture could not be induced… CONTINUE READING

From This Paper

Topics from this paper.
5 Citations
0 References
Similar Papers