The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.

@article{Sachs2013TheEO,
  title={The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.},
  author={Benjamin D. Sachs and Ramona Marie Rodriguiz and William B. Siesser and Alexander Kenan and Elizabeth L Royer and Jacob P. R. Jacobsen and William C. Wetsel and Marc G. Caron},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 9},
  pages={2081-94}
}
Aberrant serotonin (5-HT) signalling and exposure to early life stress have both been suggested to play a role in anxiety- and impulsivity-related behaviours. However, whether congenital 5-HT deficiency × early life stress interactions influence the development of anxiety- or impulsivity-like behaviour has not been established. Here, we examined the effects of early life maternal separation (MS) stress on anxiety-like behaviour and behavioural disinhibition, a type of impulsivity-like behaviour… CONTINUE READING
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