The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

@article{Takuwa1987TheEO,
  title={The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.},
  author={N. Takuwa and Y. Takuwa and W. Bollag and H. Rasmussen},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 1},
  pages={
          182-8
        }
}
Bombesin, a peptide mitogen for a variety of cell types, acts as a typical Ca2+-mobilizing hormone in Swiss 3T3 fibroblasts. At its mitogenic concentrations (1-25 nM), bombesin stimulates polyphosphoinositide turnover, i.e. breakdown of phosphatidylinositol 4,5-bisphosphate and a concomitant increase in inositol phosphates in a time- and dose-dependent manner. In particular, bombesin induces an initial transient increase in inositol 1,4,5-trisphosphate concentration, followed by an increase in… Expand
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