The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model.

@article{Xie2008TheEO,
  title={The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model.},
  author={X Xie and Yotaro Shinozawa and Jun-ichi Sasaki and Kiyotsugu Takuma and Satoshi Akaishi and Satoshi Yamanouchi and Tomoyuki Endo and Ryosuke Nomura and Michio Kobayashi and Daisuke Kudo and Nobuko Hojo},
  journal={The Journal of surgical research},
  year={2008},
  volume={146 2},
  pages={298-303}
}
BACKGROUND Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS). It has been indicated that low plasma levels of arginine are related to high mortality rates in sepsis. Arginine, however, is also known to be a precursor of NO. Therefore, administration of arginine in… CONTINUE READING