The effects of argatroban on thrombin generation and hemostatic activation in vitro.

@article{Tanaka2004TheEO,
  title={The effects of argatroban on thrombin generation and hemostatic activation in vitro.},
  author={Kenichi A Tanaka and Fania Szlam and Nobuyuki Katori and Nobukazu Sato and John David Vega and Jerrold H Levy},
  journal={Anesthesia and analgesia},
  year={2004},
  volume={99 5},
  pages={1283-9; table of contents}
}
We evaluated argatroban, a direct thrombin inhibitor, as a heparin adjunct for anticoagulation. Platelet-poor plasma (PPP) was isolated from blood collected from 12 volunteers. Thrombin generation measurements were performed in donor PPP that was mixed with antithrombin (AT)-poor plasma to yield AT levels of 0%, 20%, 60%, and 100%. Effects of argatroban (0-1.0 microg/mL), heparin (0.25 U/mL), or the combination of argatroban (0.5 microg/mL) and heparin were also studied. The addition of… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…