The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture.

@article{Ornoy2003TheEO,
  title={The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture.},
  author={Asher Ornoy and Sarah Yacobi and Shelly Tartakover Matalon and Miri Blank and Zeev Blumenfeld and Richard K. Miller and Yehuda Shoenfeld},
  journal={Lupus},
  year={2003},
  volume={12 7},
  pages={573-8}
}
Recurrent fetal loss occurs in approximately 1% of women. Autoimmune causes have been suggested as a factor in some of these cases. High rates of intrauterine fetal growth retardation and increased incidence of prematurity is associated with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). We found in previous studies that sera from SLE/APS patients when used as a culture medium for rat embryos were found to reduce embryonic growth and development, induce a high rate… CONTINUE READING
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