The effects of antidepressants in Parkinson's disease: a meta-analysis.

  title={The effects of antidepressants in Parkinson's disease: a meta-analysis.},
  author={Pasquale G. Frisina and Harriet R Tenenbaum and Joan C. Borod and Nancy S. Foldi},
  journal={The International journal of neuroscience},
  volume={118 5},
This study explored the therapeutic effect of antidepressants in Parkinson's disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p < .01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p < .01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07… CONTINUE READING


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