The effects of antibiotics on hemolytic behavior of red cells

  title={The effects of antibiotics on hemolytic behavior of red cells},
  author={Robert C. Lijana and MICHAEL C. Williams},
  journal={Cell Biophysics},
Human blood was sheared between rotating polyethylene disks and plasma hemoglobin measured at intervals to produce kinetic hemolysis curves (KHC), plotted as free hemoglobin concentration vs time. The KHC produced by blood samples incubated in the presence of penicillin, streptomycin, gentamicin, and amikacin lie always below those for control samples, indicating a reduction in hemolysis; this reduction was greater as the drug concentration was increased. Explanations in terms of alterations in… 
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Observations on shear-induced hemolysis.
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Metabolic dependence of red cell deformability.
It is proposed that the changes seen in the physical properties of ATP-depleted erythrocytes represent ATP-calcium-dependent sol-gel changes occurring at the interface between the membrane and the cell interior, and that thesol-gel balance determines membrane deformability.
Hemolytic properties of special materials exposed to a shear flow, and plasma changes with shear.
Three types of materials of special interest to the NIH Biomaterials Program were evaluated for their tendency to induce hemolysis when exposed to a laminar blood flow between rotating parallel
Stabilization of erythrocyte shape by a chemical increase in membrane shear stiffness.
A model is discussed that describes the possible mechanism by which SH reagents may stabilize the shape of the cell due to an increase of membrane shear stiffness.
Material effects in shear-induced hemolysis.
  • R. Offeman, M. Williams
  • Materials Science, Engineering
    Biomaterials, medical devices, and artificial organs
  • 1979
Failure to find time-independence in 25% of the material rankings can be attributed to inadequate control of the roughness variable, which emphasizes the importance of surface morphology, as well as surface chemistry, as a biocompatibility parameter.
Storage of red cell concentrates in CPD-A2 for 42 and 49 days.
  • E. Beutler, C. West
  • Chemistry, Medicine
    The Journal of laboratory and clinical medicine
  • 1983
High plasma hemoglobin values are observed at both 42 and 49 days' storage and may limit the usefulness of red cell concentrates stored for prolonged periods of time.
Erythrocyte damage and destruction induced by shearing stress.
Shearing stresses above a critical level resulted in overt hemolysis of some erythrocytes and damage to others evidenced by diminished survival of Cr 51 -labeled ery throats, similar to those observed in patients with prosthetic cardiac valves.
Diffusion of aminoglycoside antibiotics across the outer membrane of Escherichia coli
Results showed that aminoglycoside antibiotics diffuse through porin-pores very efficiently, as rapidly as hexoses and disaccharides, despite the fact that the molecular weights of the am inoglycosides used were higher than or close to the exclusion limit of porin pores.