The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture.

@article{Lippman1976TheEO,
  title={The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture.},
  author={Marc E. Lippman and Gail A. Bolan and Karen Huff},
  journal={Cancer research},
  year={1976},
  volume={36 12},
  pages={4610-8}
}
We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta… CONTINUE READING