The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.

@article{Weinstein1997TheEO,
  title={The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.},
  author={Robert S. Weinstein and Robert L. Jilka and A. Michael Parfitt and Stavros C Manolagas},
  journal={Endocrinology},
  year={1997},
  volume={138 9},
  pages={4013-21}
}
Both estrogens and androgens act on bone marrow stromal/osteoblastic cells to inhibit the production of local factors that promote osteoclast development. Based on this and the evidence that loss of sex steroids up-regulates not only osteoclastogenesis but also osteoblastogenesis, we have hypothesized that cells of the osteoblastic lineage are the mediators of the adverse effects of sex steroid deficiency on bone. To test this hypothesis, we used the senescence-accelerated mouse (SAMP6), a… CONTINUE READING
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