The effects of an hsp90 inhibitor on the paradoxical effect.

@article{Kaneko2009TheEO,
  title={The effects of an hsp90 inhibitor on the paradoxical effect.},
  author={Yukihiro Kaneko and Hideaki Ohno and Yoshifumi Kamakura-shi Imamura and Shigeru Kohno and Yoshitsugu Miyazaki},
  journal={Japanese journal of infectious diseases},
  year={2009},
  volume={62 5},
  pages={
          392-3
        }
}
It is important to conserve the effectiveness of antifungal agents because the options for currently available agents are limited. Although echinocandins, which have been developed in recent decades, are highly active against a broad spectrum of fungi, one concern is their reduced activity against Candida albicans at high drug concentrations, which is known as the paradoxical effect. To date, resistance related to the paradoxical effect has not been reported in clinical situations, but some in… CONTINUE READING

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