The effects of amrinone on human platelet aggregation: evidence that amrinone does not act through a cyclic nucleotide mechanism in platelet rich plasma.

The purpose of the present study was to investigate in human platelet rich plasma the effects of amrinone, a cardiotonic agent, on platelet aggregation induced by ADP, arachidonic acid (AA), collagen, prostaglandin H2 (PGH2), and U46619, a substance reported to mimic the actions of thromboxane A2. Amrinone inhibited aggregatory responses to all substances… CONTINUE READING