The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: acute time course, chronic treatment and abrupt withdrawal.

@article{Owens1991TheEO,
  title={The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: acute time course, chronic treatment and abrupt withdrawal.},
  author={Michael J. Owens and Maria Alejandra L{\'o}pez Vargas and David Knight and Charles B. Nemeroff},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={258 1},
  pages={349-56}
}
Considerable evidence indicates that corticotropin-releasing factor (CRF) is responsible for integrating not only the endocrine, but the autonomic and behavioral responses of an organism to stress. We have investigated the time course of action of the anxiolytic triazolobenzodiazepine, alprazolam, on the activity of the hypothalamic-pituitary-adrenal (HPA) axis and of CRF neurons after acute and chronic administration. In addition, because many of the signs and symptoms observed in animals and… CONTINUE READING
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