The effects of alprazolam on conditioned place preferences produced by intravenous heroin

  title={The effects of alprazolam on conditioned place preferences produced by intravenous heroin},
  author={B. Walker and A. Ettenberg},
  journal={Pharmacology Biochemistry and Behavior},
  • B. Walker, A. Ettenberg
  • Published 2003
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • Case studies reveal that opiate addicts often self-medicate with benzodiazepine (BDZ) tranquilizers prior to taking their opiate. Our laboratory has previously utilized the conditioned place preference paradigm to confirm that BDZs can augment the affective response to heroin in laboratory animals. The combination of alprazolam and varying doses of intravenous heroin resulted in a leftward shift of the heroin dose-response curve. The present experiment was devised to extend the previous… CONTINUE READING
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