The effects of alprazolam on conditioned place preferences produced by intravenous heroin

  title={The effects of alprazolam on conditioned place preferences produced by intravenous heroin},
  author={Brendan M Walker and Aaron Ettenberg},
  journal={Pharmacology Biochemistry and Behavior},

exmedetomidine induces conditioned place preference in rats : nvolvement of opioid receptors uğç

The results suggest that DEX produces CPP effects similar to morphine in rats and that opioidergic mechanism may be responsible for DEX-induced CPP, which might have the potential to be addictive.

Self-Administration of Fentanyl-Alprazolam Combinations by Rhesus Monkeys Responding under a Progressive-Ratio Schedule

It is shown that combinations of the opioid fentanyl and the benzodiazepine alprazolam can be more reinforcing than either drug alone in a rhesus monkey model, suggesting that enhancement of reinforcement processes may underlie this prevalent form of polydrug use disorder.

Lorazepam reinstates punishment-suppressed remifentanil self-administration in rats

This is the first demonstration that a trigger for relapse may have different effects depending on whether aversive conditioning contributed to the achievement of abstinence, and may be important to consider potential antipunishment effects of both abused drugs and therapeutic agents in the treatment of individuals with a history of drug abuse.

Effects of propofol on conditioned place preference in male rats: Involvement of nitrergic system

The results suggest that propofol produces CPP effects in rats and that NO-related mechanisms may be responsible for prop ofol-induced CPP.

Reinforcing effectiveness of midazolam, ethanol, and sucrose: behavioral economic comparison of a mixture relative to its component solutions

The finding that the reinforcing effectiveness of the SME was less than that of SM does not support the supposition that BZ and ethanol coadministration is maintained by an enhanced reinforcing effect of the mixture.

Gabab Regulation of Methamphetamine-Induced Associative Learning

Data indicate that the maintenance of Meth-induced associative learning can be disrupted by post-conditioning administration of 10 once-daily home cage injections of baclofen, and this inhibitory effect was not observed when bacl ofen was administered for two days independent of when those two injections were administered.

Social defeat stress switches the neural system mediating benzodiazepine conditioned motivation.

Midazolam reinforcement in the conditioned place preference paradigm was shown to be predictive for dominance/submission status and stress is sufficient for switching the neural system mediating midazlam conditioned motivation.

Polydrug abuse: a review of opioid and benzodiazepine combination use.



Benzodiazepine modulation of opiate reward.

Results demonstrated that alprazolam produced a leftward shift of the heroin dose-response curve in the conditioned place preference test, consistent with the view that BDZs can augment the affective response to heroin in laboratory animals.

Reinforcing effects of morphine microinjection into the ventral tegmental area

Adjunctive drug use among opiate addicts.

In a study of 249 opiate (mainly heroin) addicts, it is shown that heroin addiction is the major problem, and the use of adjunctive drugs, especially benzodiazepines, can be partly explained on economic grounds.

Alprazolam abuse during methadone maintenance therapy.

Alprazolam (Xanax), a short-acting triazolobenzodiazepine, has been demonstrated to be a potent anxiolytic, 1 efficacious for panic disorder and is being used and abused by nonopiate-drug abusers much as diazepam was abused prior to increased physician awareness.

Diazepam and methadone interactions in methadone maintenance

Diazepam with Methadone in methadone maintenance appears to increase some physiologic and subjective opioid effects that may be related to the relatively great use/abuse of diazepam in this population.

Opponent Process Model and Psychostimulant Addiction

Peripherally administered benzodiazepines increase morphine-induced analgesia in the rat. Effect of RO 15-3505 and FG 7142.

The results suggest that the interaction between Benzodiazepines and opioids in modulating nociceptive responses involves primarily benzodiazepine receptors and that different pathways are involved in the anxiolytic and pro-analgesic actions of benzdiazepines.

Effects of centrally administered anxiolytic compounds in animal models of anxiety