Corpus ID: 29544272

The effects of alpha-2 agonists and antagonists on gastric acid secretion.

  title={The effects of alpha-2 agonists and antagonists on gastric acid secretion.},
  author={C. Bernardini and Mario del Tacca and Giulio Soldani and Enrica Martinotti},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={281 1},
The effects of alpha-2 agonists clonidine, xylazine and guanabenz as well as those of alpha-2 antagonists tolazoline and yohimbine on gastric acid secretion were investigated in Shay rats, Schild rats and isolated guinea-pig gastric fundus. In Shay rats clonidine, xylazine and guanabenz displayed marked antisecretory effects, whereas tolazoline and yohimbine had no effect. Under the same conditions, yohimbine fully prevented the actions of clonidine, xylazine and guanabenz, while tolazoline… Expand
Effect of α2‐adrenoceptor agonists on gastric pepsin and acid secretion in the rat
1 The purpose of the present study was to analyze the effects of the α2‐adrenoceptor agonists clonidine, guanabenz, detomidine and medetomidine on pepsin secretion in conscious rats provided withExpand
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Central alpha-2 adrenoceptors regulate central and peripheral functions.
Evidence has been provided that clonidine decreases blood pressure, inhibits salivary secretion and reduces gastrointestinal secretion and motility, whereas novel imidazoline derivatives, such as detomidine, display sedative and analgesic properties which have been related to the activation of central alpha-2 adrenoceptors. Expand
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