The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.

@article{Mukherjee1997TheEO,
  title={The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.},
  author={Suman K. Mukherjee and James David Adams},
  journal={Molecular and chemical neuropathology},
  year={1997},
  volume={32 1-3},
  pages={59-74}
}
In this work, the tertiary butylhydroperoxide- (t-BuOOH) treated mouse was used as a model to study the oxidative stress that is associated with various neurodegenerative diseases. DNA was found to be an early target of t-BuOOH attack. Necrosis was associated with extensive DNA fragmentation that occurred in almost all regions of the brain within 20 min following intracerebroventricular (icv) injection of 109.7 mg/kg t-BuOOH. Apoptosis was associated with high levels of DNA fragmentation that… CONTINUE READING

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