The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles.

@article{Donato2005TheEO,
  title={The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles.},
  author={Anthony John Donato and Lisa A. Lesniewski and Michael Delp},
  journal={Cardiovascular research},
  year={2005},
  volume={66 2},
  pages={393-401}
}
OBJECTIVES The incidence of cardiovascular disease increases with advancing age. Vascular dysfunction has been linked to cardiovascular disease and aging, although most research has focused on endothelium-dependent vasodilator dysfunction. Another possible mechanism for this vascular dysfunction with aging is enhanced vasoconstrictor responsiveness of the… CONTINUE READING