The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.

@article{Davis1985TheEO,
  title={The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.},
  author={Dwight D. Davis and Steven Howard Grossman and Barbara B. Kitchell and David J. Shand and Philip Alexander Routledge},
  journal={British journal of clinical pharmacology},
  year={1985},
  volume={19 2},
  pages={
          261-5
        }
}
In 63 healthy ambulant subjects 18 to 88 years of age, the plasma protein binding of diazepam (principally bound to albumin) decreased with age. Diazepam binding in plasma correlated positively with plasma albumin concentration which also decreased with age. In contrast, the plasma protein binding of the basic drug, lignocaine (predominantly bound to alpha 1-acid glycoprotein [AAG]), tended to increase slightly with age. Lignocaine binding in plasma correlated positively with plasma AAG… CONTINUE READING
BETA