The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons.

@article{Mouton2012TheEO,
  title={The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons.},
  author={Peter R. Mouton and Bennett Kelley-Bell and David Tweedie and Edward L. Spangler and Esther P{\'e}rez and Olga D Carlson and Ryan G Short and Rafael Decabo and Jianjun Chang and Donald K. Ingram and Yanhui Li and Nigel H. Greig},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 2},
  pages={423.e27-36}
}
Parkinson's disease (PD), an age-related movement disorder, is characterized by severe catecholaminergic neuron loss in the substantia nigra pars compacta (SN(PC))-ventral tegmental area (VTA) and locus coeruleus (LC). To assess the stability of these central catecholaminergic neurons following an acute episode of severe inflammation, 6 to 22 month old C57/Bl6 mice received a maximally tolerated dose of lipopolysaccharide (LPS) followed by euthanasia 2 hours later to assay peak levels of… CONTINUE READING
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