The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum

@article{Kosterlitz1970TheEO,
  title={The effects of adrenaline, noradrenaline and isoprenaline on inhibitory $\alpha$‐ and $\beta$‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum},
  author={H. Kosterlitz and R. J. Lydon and A. Watt},
  journal={British Journal of Pharmacology},
  year={1970},
  volume={39}
}
1 Two preparations, a segment of the ileum and the myenteric plexus‐longitudinal muscle preparation, have been used for an analysis of the inhibitory effects of adrenaline, noradrenaline and isoprenaline on the contractor responses of the longitudinal muscle to acetylcholine or to electrical, coaxial or field, stimulation. 2 Since the inhibitory effects of adrenaline, noradrenaline and isoprenaline on the acetylcholine‐induced contractions were not affected by phenoxybenzamine but were… Expand
DISTRIBUTION AND TYPES OF ADRENOCEPTORS IN THE GUINEA‐PIG ILEUM: THE ACTION OF α‐ AND β‐ADRENOCEPTOR AGONISTS
1 Segments of guinea‐pig ileum and the myenteric plexus‐longitudinal smooth muscle preparation were used for a study of the actions of adrenaline, noradrenaline, isoprenaline, ephedrine andExpand
Alpha- and beta-adrenoceptor-mediated responses of the guinea-pig ileum and the effects of neuronal uptake inhibition
TLDR
Alpha- or beta-adrenoceptor-mediated responses were examined by construction of cumulative concentration-response curves in the presence of propranolol and phentolamine and may be considered to be closely associated with the sympathetic innervation. Expand
Inhibitory and excitatory effects of sympathomimetic amines on muscle strips from the stomach of the guinea‐pig
  • D. Bailey
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1971
TLDR
It is concluded that the adrenoceptors mediating the responses recorded from these preparations are located on the smooth muscle cells rather than on a nervous pathway. Expand
THE EFFECTS OF PRAZOSIN, PHENTOLAMINE AND PHENOXYBENZAMINE ON INHIBITORY α‐ADRENOCEPTORS IN THE GUINEA‐PIG ISOLATED ILEUM
1 The relaxant effect of noradrenaline on strips of guinea‐pig isolated terminal ileum was blocked by pretreatement with prazosin, phentolamine, yohimbine and phenoxybenzamine. 2 The presence of aExpand
PHARMACOLOGICAL CHARACTERIZATION OF THE PRESYNAPTIC α‐ADRENOCEPTORS REGULATING CHOLINERGIC ACTIVITY IN THE GUINEA‐PIG ILEUM
  • G. M. Drew
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1978
TLDR
The results demonstrate that the presynaptic α‐adrenoceptors in the guinea‐pig ileum are of the same type as those located presynaptically in sympathetically innervated tissues. Expand
Inhibition of Guinea-Pig Taenia Coli Mediated by eti-, f}2-Adrenoceptors and ATP-Receptor Activation
The actions of or- and /8-adrenoceptor agonists, antagonists and ATP were investigated on the smooth muscle of the guinea-pig taenia coli. Electrical and mechanical activities were recorded by meansExpand
INHIBITORY ACTIONS OF CATECHOLAMINES ON ELECTRICALLY INDUCED CONTRACTIONS OF THE SUBMUCOUS PLEXUS‐LONGITUDINAL MUSCULARIS MUCOSAE PREPARATION OF THE GUINEA‐PIG OESOPHAGUS
TLDR
The submucous plexus‐longitudinal muscularis mucosae preparation of the guinea‐pig oesophagus was used to study the actions of catecholamines on the twitch responses to electrical stimulation, and cholinergic neurotransmission is inhibited by catecholinamines acting at both prejunctionsal α‐ and postjunctional β‐adrenoceptors. Expand
Characterization of receptors on postganglionic cholinergic neurons in the guinea‐pig isolated ileum
TLDR
The results suggest that there are two populations of prejunctional receptors on the cholinergic nerves innervating the smooth muscle of the guinea‐pig ileum, one receptor is similar to a classical preJunctional α‐adrenoceptor and the other resembles a central dopamine receptor. Expand
Effects of 3,4‐diaminopyridine and tetraethylammonium on the pre‐ and post‐junctional α‐adrenoceptor mediated inhibitory actions of noradrenaline in the guinea‐pig ileum
1 The effects of potassium channel blockers, 3,4‐diaminopyridine (DAP) and tetraethylammonium (TEA) were studied on the pre‐ and post‐junctional α2‐adrenoceptor mediated effects of noradrenaline inExpand
THE INHIBITORY EFFECTS OF PRESYNAPTIC α‐ADRENOCEPTOR AGONISTS ON CONTRACTIONS OF GUINEA‐PIG ILEUM AND MOUSE VAS DEFERENS IN THE MORPHINE‐DEPENDENT AND WITHDRAWN STATES PRODUCED in vitro
TLDR
A possible explanation is suggested for the loss of the inhibitory effects of presynaptic α‐adrenoceptor agonists in the withdrawn state of the dependent ileum. Expand
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