The effects of administration of meta-tyramine and para-tyramine on dopamine and its metabolites in the rat striatum

  title={The effects of administration of meta-tyramine and para-tyramine on dopamine and its metabolites in the rat striatum},
  author={Paul S. Mcquade and Paul L. Wood},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • P. Mcquade, P. Wood
  • Published 31 December 1984
  • Biology, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
2 Citations
Prolactin inhibition by p-tyramine in the male rat: site of action.
The present results indicate that tyramine can inhibit PRL release due to certain drugs, by acting directly at the pituitary level, and octopamine, which lowersPRL release itself, cannot account for the effect of tyramsine.
Differential Responsiveness of LH and Prolactin to p-Tyramine in Male and Female Rats
  • D. Becu-VillalobosC. Libertun
  • Biology, Psychology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1988
The present results suggest that p-tyramine may be involved not only in prolactin regulation as it has been previously shown, but also in LH control, and that the hormonal response to this amine is sexually differentiated in the rat.


The effects of β-phenylethylamine on tyramine and dopamine metabolism
  • P. McquadeP. Wood
  • Chemistry
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1983
The Effect of Mesencephalic Lesions on Tyramine and Dopamine in the Caudate Nucleus of the Rat
The results suggest that p‐ and m‐tyramine in the caudate nucleus originate from neurons in or close to the substantia nigra, and support the observation that there is an inverse relationship between p‐TYramine concentration and DA turnover in the Caudates nucleus.
Interactions between p-tyramine, m-tyramine, or beta-phenylethylamine and dopamine on single neurones in the cortex and caudate nucleus of the rat.
The results may suggest that trace amines can enhance NA and DA transmission in the central nervous system.
Involvement of nigro-striatal neurons in the in vivo release of dopamine by amphetamine, amantadine and tyramine.
The efflux of 3H-dopamine evoked from central dopaminergic synapses by amphetamine and amantadine is primarily dependent upon the impulse activity of neurons in the nigro-striatal pathway; the release by tyramine, although arising from the same terminals, is not dependent upon ongoing impulse activity.
On the Significance of Endogenous 3‐Methoxytyramine for the Effects of Centrally Acting Drugs on Dopamine Release in the Rat Brain
3‐MT seems to be a much better indicator for decreased DA release than 3,4‐dihydroxyphenylacetic acid or homovanillic acid, and is concluded that a decreased release of DA is closely and rapidly reflected by decreased formation of 3‐MT.
Effects of various antipsychotic drugs upon the striatal concentrations of para‐hydroxyphenylacetic acid and meta‐hydroxyphenylacetic acid in the mouse
The results suggest that antipsychotic drugs increase the utilization of mouse striatal p‐ and m‐tyramine and that after use the amines are metabolized by monoamine oxidase to form p‐ or m‐hydroxyphenylacetic acid.