The effects of acute and repeated administration of ketamine on attentional performance in the five-choice serial reaction time task in rats.

@article{Nikiforuk2014TheEO,
  title={The effects of acute and repeated administration of ketamine on attentional performance in the five-choice serial reaction time task in rats.},
  author={Agnieszka Nikiforuk and Piotr Popik},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2014},
  volume={24 8},
  pages={1381-93}
}
Ketamine, the non-competitive antagonist of the N-methyl-d-aspartate receptors, is used in clinical and preclinical studies to produce schizophrenia-like cognitive impairments. However, the impact of ketamine on attentional functions remains poorly characterised. In the present study, we further examine the effects of ketamine on attentional processes assessed in the five-choice serial reaction time task (5-CSRTT) in rats. The applied schedules of ketamine administration have been previously… CONTINUE READING
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