The effects of activated factor VII in a cell-based model for tissue factor-initiated coagulation.

@article{Kjalke1998TheEO,
  title={The effects of activated factor VII in a cell-based model for tissue factor-initiated coagulation.},
  author={Marianne Kjalke and Dougald M Monroe and Maureane R Hoffman and Jes{\'u}s Argente Oliver and Mirella Ezban and Ulla Hedner and HaroldR. Roberts},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1998},
  volume={9 Suppl 1},
  pages={
          S21-5
        }
}
The importance of activated factor VII (FVIIa) in coagulation initiated by tissue factor (TF) was illustrated by competition of active site-inhibited FVIIa (FFR-FVIIa; FVIIa treated with D-Phe-Phe-Arg-chloromethyl ketone) with FVIIa in various cell-based assays mimicking TF-initiated coagulation. FFR-FVIIa inhibited the overall initiation process as measured by platelet activation and large-scale thrombin generation on the activated platelet surface. When the individual steps in the initiation… CONTINUE READING