The effects of acrylonitrile on hemoglobin and red cell metabolism.

The effects of acrylonitrile (VCN) on hemoglobin and red cell metabolism were studied in vitro and in vivo using male Sprague-Dawley rats. Reduced glutathione (GSH) was rapidly depleted by VCN. The reaction between VCN and GSH to form S-cyanoethyl glutathione is both enzymic and nonenzymic. GSH depletion induced oxidation of considerable amount of… CONTINUE READING