The effects of acrolein exposure on pulmonary antibacterial defenses.

Inhalation exposure to acrolein induced a dose-dependent impairment of pulmonary antibacterial defenses in mice. Animals exposed to 3 or 6 ppm of acrolein were increasingly less effective in inactivation of aerogenic challenges of 32P-labeled Staphylococcus aureus. Acrolein concentrations greater than 6 ppm caused increased sensory irritations, but no… (More)