The effects of acrivastine (BW825C), diphenhydramine and terfenadine in combination with alcohol on human CNS performance

  title={The effects of acrivastine (BW825C), diphenhydramine and terfenadine in combination with alcohol on human CNS performance},
  author={Adam F. Cohen and M. J. Hamilton and Anthony W. Peck},
  journal={European Journal of Clinical Pharmacology},
SummaryTwo studies were performed to measure the effects of acrivastine (BW825C), an antihistamine, in combination with alcohol on the central nervous system. In one study acrivastine 8 mg, diphenhydramine 50 mg and alcohol 32 ml were administered alone and in combination and compared with placebo. In a second study terfenadine 60 and 120 mg and acrivastine 4 and 8 mg combined with alcohol 32 ml were compared with placebo and alcohol alone. Each study was a double-blind, randomised cross-over… 
Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing
In conclusion, the normal therapeutic dose of acrivastine (8 mg) had little effect on driving performance, and virtually none when that dose was given in combination with pseudoephedrine (60 mg).
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
The results show that the effect profile of TPA023 differs markedly from that of Lorazepam, at doses that were equipotent with regard to effects on saccadic peak veLocity, and these differences reflect the selectivity of T PA023 for different GABAA receptor subtypes.
The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers
This study showed that the three doses of SL65.1498 were well tolerated and induced no impairments on memory, sedation, psychomotor, and cognitive functions, which are believed to be mediated by the alpha1 and alpha5 subtypes.
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Despite the absence of significant synergistic interactions, unanticipated impairment of performance may occur in susceptible individuals when taking combined low doses of alcohol and diazepam.
Effects of diphenhydramine on human eye movements
It is suggested that, like diazepam, diphenhydramine causes sedation, SEV slowing, and an increase in saccade latency, and different neurotransmitter systems may influence the neural pathways involved in SEV and smooth pursuit gain.
Antiemetics With Concomitant Sedative Use in Civil Aviation Pilot Fatalities: From 2000 to 2006
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Cognitive domains affected by histamine H1-antagonism in humans: A literature review
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Adverse drug interactions in dentistry.
According to the United States Food and Drug Administration web site, there are more than 15,000 currently approved prescription and over-the-counter drugs, diagnostics and intravenous supplementation products in the US and the potential for adverse drug interactions is a growing concern for all fields of patient care including dental medicine.


Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine.
Terfenadine (60 mg) and astemizole (10 and 20 mg) are likely to prove useful antihistamines for those involved in skilled activity.
Performance studies with antihistamines.
The subjects as a group reported improved alertness and improved wakefulness and were less energetic 7.0 h after ingestion of chlorpheniramine, and were not other consistent changes in assessments of well-being.
Pharmacodynamic and pharmacokinetics of BW 825C: A new antihistamine
It was concluded that BW 825C might be a clinically active H1-antagonist with reduced sedative side-effects.
Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
SummaryThe effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were
Effects of amitriptyline and zimelidine in combination with ethanol
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Drug Kinetics and Alcohol Ingestion
Systematic studies of the mechanism of alcohol kinetic interactions are needed and such kinetic studies should be combined with pharmacodynamic measures in order to establish the clinical importance of changes in drug kinetics.
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Subjective assessments of performance correlated with measured performance, but the subjects, as a group, over-estimated their performance after placebo and heptabarbitone, and the blood concentrations and performance decrements at each dose were related.
The action of sedatives on brain stem oculomotor systems in man.
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  • Psychology, Medicine
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Nitrazepam had significantly less oculomotor effect but significantly more subjective effects than phenobarbitone, related to theevidence that smooth tracking suppression arises from drug action on brain stem systems, and the evidence that benzodiazepines affect brain stem Systems less than the limbic system.
Benzodiazepines impair smooth pursuit eye movements.
The relationship between serum benzodiazepine concentration and its effect on an objective measure of oculomotor performance is demonstrated and log-linearly correlated with serum temazepam and diazepam concentration.
An efficient technique for determining characteristics of saccadic eye movements using a mini computer.
A new technique has been developed to quantify objectively certain characteristics of saccadic eye movements which can be used as indices of the effect of centrally-acting compounds, and the peak velocity characteristic has been identified as a sensitive measure of the effects of several benzodiazepines.