The effects of a shampoo containing zinc pyrithione on the control of dandruff

  title={The effects of a shampoo containing zinc pyrithione on the control of dandruff},
  author={Ronald Marks and Anthony Dalton Pearse and Arthur P. Walker},
  journal={British Journal of Dermatology},
Thirty‐two subjects who suffered from dandruff participated in a study in which one‐half of the head was washed with a shampoo containing 1% zinc pyrithione (ZPT) and the other half was washed with the same shampoo without ZPT. Four groups, eight subjects per group, were shampooed one, three, six or nine times (shampoo frequency twice per week). Clinical dandruff gradings of each half of the head were made 4 days after the last shampoo in each group, when scalp biopsy samples were also taken… 

Enhanced efficacy and sensory properties of an anti‐dandruff shampoo containing zinc pyrithione and climbazole

The most common treatment for dandruff is the use of shampoo formulations that contain fungistatic agents such as zinc pyrithione (ZPT) and octopirox, but these shampoos can often result in hair condition that is less than acceptable to consumers which can lead to a tendency to revert to use of a non‐antidandruff shampoo.

Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment.

The global efficacy of the 2 antifungal treatments assessed at day 28 by both investigator and patient was significantly better than that of the vehicle and only the CPO/ZP shampoo improved all DLQI questionnaire dimensions.

Multicenter, open-label, non-comparative study of a combination of polytar and zinc pyrithione shampoo in the management of dandruff.

A combination shampoo of polytar (1%) and zinc pyrithione ( 1%) offers a safe and effective option in the treatment of dandruff and its associated symptoms.

Estrogenic activity of zinc pyrithione: an in vivo and in vitro study

In vivo and in vitro assays demonstrated that ZP showed no significant estrogenic activity, and changes in gene expression slightly differed between the ZP and control groups.

Antidandruff shampoos and the stratum corneum

It is concluded that the formulation of shampoos for dandruff should not be overlooked and the activity against corneocyte clumping showed significant differences among the test products.

Shampoos: Ingredients, efficacy and adverse effects

  • R. Trüeb
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2007
Recent developments in shampoo technology have led to increased efficacy of anti‐dandruff agents, allowing shorter contact time, and reducing irritation.

Stratum corneum dysfunction in dandruff

Dandruff is characterized by a flaky, pruritic scalp and affects up to half the world’s population post‐puberty, and treatment of dandruff with cosmetic products to directly improve SC integrity while providing effective antifungal activity may thus be beneficial.

Revisiting dandruff

Dandruff is a common scalp disorder affecting almost half of the postpubertal population of any ethnicity and both genders. It may, however, represent a stubborn esthetical disturbance often source

In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

In vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species is demonstrated and underscores its potential interest in the treatment of seborrheic dermatitis.

Targeted Delivery of Zinc Pyrithione to Skin Epithelia

Future research is expected to yield further advances in ZnPT formulations for SD and also include re-purposing towards a range of other dermatologic applications, which is likely to have significant clinical impact.



Role of microorganisms in dandruff.

The studies demonstrate that the increased number of scalp microorganisms found in dandruff occurs as a secondary event to increased nutrients and that scalp organisms play no primary role in the pathogenesis of d andruff.

Antimicrobial effect of zinc pyrithione

Quantitative estimation of scalp microorganisms revealed that corresponding to the decrease in dandruff, Pityrospbrum ovale were specifically lowered by zinc pyrithione treatments, but not by Irgasan DP-300 ©.


  • S. Shuster
  • Medicine
    The British journal of dermatology
  • 1984
I reviewed the publications exposed by a Medlars Toxline and Toxback search, including some in the increasingly overlapping area of seborrhoeic dermatitis and psoriasis, as well as a number of internal reports made available by Procter & Gamble.

The effect of hair care products on dandruff

Although the role of micro‐organisms located on the surface of the scalp is disputed by some authors, lipolytic organisms within the hair follicle may still be implicated in the causation of dandruff and effective anti‐dandruff compounds display good antimicrobial activity.

Efficiency of Antiseptics When Acting on Dried Organisms

A group of compounds which was originally presented to virologists as a tool for studying the nucleic acid of the virus has just been shown to have a chemotherapeutic effect on herpetic infections of the eye of man.

Acute toxicity of Zinc pyrithione to human skin cells in vitro.

The results suggest that zinc pyrithione's action against dandruff is more likely to arise from a non-specific toxicity for epidermal cells than by an anti-mitotic effect or by remedying a local zinc deficiency.

Epidermal architecture, growth, and metabolism in acromegaly.

Epidermal architecture, replication, and anabolic activity were studied in six patients with acromegaly and none of the changes observed could be closely correlated with levels of serum growth hormone.

Study of lysosomal enzyme release by microspectrofluorometry on single cells

In preliminary experiments, in vivo lysosomal membrane rupture and enzyme release is studied using the high sensitivity of the microspectrofluorometric technique (Kohen ei al.., 1981b) that allows one to follow the fluorescence of a single living cell.

Growth Characteristics of the Epidermis in the Ichthyotic Disorders

No serious disturbance of the rate of epidermal cell production in autosomal dominant ichthyosis is found, however, a high rate ofEpidermopoiesis was noted in non-bullous ICHthyosiform erythroderma by Frost1.

Is There a Relationship between Clinical Morphology and Epidermal Cell Kinetics?

  • R. Marks
  • Medicine, Biology
    Proceedings of the Royal Society of Medicine
  • 1975
Capillary microscopy is a useful tool with which to recognize the failure of the epidermis to induce a normal dermis, and while agreeing and admiring the concepts developed by Pinkus (1970) which concern stroma it will be seen that I am not convinced that the aim of theEpidermis is habitually outwards.