The effects of a shampoo containing zinc pyrithione on the control of dandruff

@article{Marks1985TheEO,
  title={The effects of a shampoo containing zinc pyrithione on the control of dandruff},
  author={Ronald Marks and Anthony Dalton Pearse and Arthur P. Walker},
  journal={British Journal of Dermatology},
  year={1985},
  volume={112}
}
Thirty‐two subjects who suffered from dandruff participated in a study in which one‐half of the head was washed with a shampoo containing 1% zinc pyrithione (ZPT) and the other half was washed with the same shampoo without ZPT. Four groups, eight subjects per group, were shampooed one, three, six or nine times (shampoo frequency twice per week). Clinical dandruff gradings of each half of the head were made 4 days after the last shampoo in each group, when scalp biopsy samples were also taken… 

Enhanced efficacy and sensory properties of an anti‐dandruff shampoo containing zinc pyrithione and climbazole

The most common treatment for dandruff is the use of shampoo formulations that contain fungistatic agents such as zinc pyrithione (ZPT) and octopirox, but these shampoos can often result in hair condition that is less than acceptable to consumers which can lead to a tendency to revert to use of a non‐antidandruff shampoo.

Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment.

The global efficacy of the 2 antifungal treatments assessed at day 28 by both investigator and patient was significantly better than that of the vehicle and only the CPO/ZP shampoo improved all DLQI questionnaire dimensions.

Multicenter, open-label, non-comparative study of a combination of polytar and zinc pyrithione shampoo in the management of dandruff.

A combination shampoo of polytar (1%) and zinc pyrithione ( 1%) offers a safe and effective option in the treatment of dandruff and its associated symptoms.

Estrogenic activity of zinc pyrithione: an in vivo and in vitro study

In vivo and in vitro assays demonstrated that ZP showed no significant estrogenic activity, and changes in gene expression slightly differed between the ZP and control groups.

Antidandruff shampoos and the stratum corneum

It is concluded that the formulation of shampoos for dandruff should not be overlooked and the activity against corneocyte clumping showed significant differences among the test products.

Shampoos: Ingredients, efficacy and adverse effects

  • R. Trüeb
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2007
Recent developments in shampoo technology have led to increased efficacy of anti‐dandruff agents, allowing shorter contact time, and reducing irritation.

Stratum corneum dysfunction in dandruff

Dandruff is characterized by a flaky, pruritic scalp and affects up to half the world’s population post‐puberty, and treatment of dandruff with cosmetic products to directly improve SC integrity while providing effective antifungal activity may thus be beneficial.

Revisiting dandruff

Dandruff is a common scalp disorder affecting almost half of the postpubertal population of any ethnicity and both genders. It may, however, represent a stubborn esthetical disturbance often source

In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

In vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species is demonstrated and underscores its potential interest in the treatment of seborrheic dermatitis.

Targeted Delivery of Zinc Pyrithione to Skin Epithelia

Future research is expected to yield further advances in ZnPT formulations for SD and also include re-purposing towards a range of other dermatologic applications, which is likely to have significant clinical impact.
...

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