The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.

  title={The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.},
  author={John F Marshall and Adria S. Bhatnagar and Susan G. Bowman and Natalie N. Morris and Dinah A. Skorich and Caitlyn D Redding and Anthony T. Blikslager},
  journal={Equine veterinary journal. Supplement},
REASONS FOR PERFORMING STUDY Flunixin meglumine is used for treatment of equine colic despite evidence of inhibited recovery of mucosal barrier function following small intestinal ischaemic injury. This study aimed to characterise an alternative treatment (AHI-805) for abdominal pain in the horse. OBJECTIVE To determine the effect of AHI-805, an aza-thia-benzoazulene derivative, on the cyclooxygenase enzymes and the recovery of mucosal barrier function following ischaemic injury. METHODS… 

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Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.
Robenacoxib selectively inhibited COX-2 and allowed recovery of barrier function in ischemia-injured equine jejunal tissue in vitro.
Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum.
Treatment of horses with ischaemic jejunal disease with flunixin may result in a prolonged permeability defect in recovering mucosa, which may have implications for the use of nonsteroidal anti-inflammatory drugs in colic patients.
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum.
It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic.
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum.
Evaluated the clinical importance of flunixin-associated delayed mucosal recovery requires further in vivo investigation, and ischemia increased LPS passage across equine jejunal mucosa.
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia.
Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol.
In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.
The novel DFU was the most selective COX-2 inhibitor in equine, canine, and feline blood, compared with phenylbutazone, flunixin meglumine, and carprofen and may result in a lower incidence of adverse effects compared with NSAID.
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
Treatment with systemic lidocaine ameliorated the inhibitory effects of flunixin meglumine on recovery of the mucosal barrier from ischaemic injury, when the 2 treatments were combined.
The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury.
Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs
Analysis of the ratio of inhibition ofCOX-1 to COX-2 by non-steroidal anti-inflammatory drugs, suggests inhibitors can be classified based on their COX selectivity, and human pharmacology studies concentrating on the inhibition of prostanoid synthesis in target tissues are of paramount importance in determining the clinical relevance of COx-2 selectivity.
Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion.
PGs signal recovery of Rvia induction of Cl-secretion and inhibition of Na+absorption, possibly by establishing a transmucosal osmotic gradient.