The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice

@article{Antflick2009TheEO,
  title={The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice},
  author={Jordan E. Antflick and Glen B Baker and David R. Hampson},
  journal={Amino Acids},
  year={2009},
  volume={39},
  pages={145-153}
}
l-Serine is required for cellular and tissue growth and is particularly important in the immature brain where it acts as a crucial neurotrophic factor. In this study, the levels of amino acids and enzymes in the l-serine biosynthetic pathway were examined in the forebrain, cerebellum, liver, and kidney after the exposure of mice to protein-restricted diets. The levels of l-serine, d-serine, and l-serine-O-phosphate were quantified by HPLC and quantitative Western blotting was used to measure… CONTINUE READING