The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity.

@article{Lin1998TheEO,
  title={The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity.},
  author={X. Q. Lin and M. Chavez and Richard C. Bruch and Gail E. Kilroy and Lisa A Simmons and L. Lin and Hugh D Braymer and George A. Bray and David A. York},
  journal={The Journal of nutrition},
  year={1998},
  volume={128 10},
  pages={1606-13}
}
Osborne-Mendel (OM) and S5B/Pl rats differ in their sensitivity to develop obesity when fed a high fat (HF) diet; OM rats become obese, whereas S5B/Pl rats remain thin. We have investigated the possibilities that either an impaired leptin response or resistance to leptin action underlies the sensitivity to this form of obesity in OM rats. In Experiment 1, OM and S5B/Pl rats fed a nonpurified diet were killed at d 0 or were fed either a HF (56% fat energy) or a low fat (LF, 10% fat energy) diet… CONTINUE READING

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