The effects of a converting enzyme inhibitor (captopril) and angiotensin II on fetal renal function.

@article{Lumbers1993TheEO,
  title={The effects of a converting enzyme inhibitor (captopril) and angiotensin II on fetal renal function.},
  author={Eugenie R Lumbers and Judith H Burrell and Robert Menzies and Arianne D Stevens},
  journal={British journal of pharmacology},
  year={1993},
  volume={110 2},
  pages={
          821-7
        }
}
1. Renal function was studied in chronically catheterized fetal sheep (119-128 days gestation), before and during treatment of the ewe with the angiotensin converting enzyme (ACE) inhibitor, captopril, which crosses the placenta and blocks the fetal renin angiotensin system. 2. An i.v. dose of 15 mg (about 319 micrograms kg-1) of captopril to salt-replete ewes followed by an infusion to the ewe of 6 mg h-1 (about 128 micrograms kg-1 h-1) caused a fall in fetal arterial pressure (P < 0.01), and… CONTINUE READING
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