INTRODUCTION The aim of this in vitro study was to evaluate the effect of various irrigants on the push-out bond strength of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA). METHODS AND MATERIALS A total of 140 dentin disks with a thickness of 1.5±0.2 mm and lumen size of 1.3 mm, were randomly divided into 12 groups (n=10) and 4 control groups (n=5). The lumen of disks in groups 1, 2, 3, 7, 8, 9 were filled with CEM and groups 4, 5, 6, 10, 11, 12 were filled with MTA. Control groups were filled with CEM and MTA. Specimens were incubated at 37°C for one day in groups 1 to 6 and seven days in groups 7 to 12. After incubation the samples were divided into three subgroups (n=10) that were either immersed for 30 min in 5.5% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX) or saline solution. The push-out bond strength values were measured by using a universal testing machine. The nature of the failures were determined by light microscope. Data was analyzed using the three-way ANOVA to evaluate the effect of material type, different irrigants and time intervals. Post hoc Tukey's test was used for two-by-two comparison of the groups. RESULTS CEM cement significantly showed a higher push-out bond strength in comparison with MTA (P=0.001). The elapse of time significantly increased the bond strength (P=0.001). There was no significant difference between the irrigants used in this study (P=0.441). Bond failure was predominantly of mixed type in MTA and of cohesive type in CEM samples. CONCLUSION Based on this study, endodontic irrigants did not influence the push-out bond strength of MTA and CEM cement.