The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men.

@article{Siepmann2002TheEO,
  title={The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men.},
  author={Martin Siepmann and Stephanie Krause and Peter Joraschky and Michael Mueck-Weymann and Wilhelm Kirch},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={54 3},
  pages={277-82}
}
AIMS To compare the effects of multiple dosing with St John's wort (Hypericum perforatum) extract and amitriptyline on heart rate variability, cognitive function and quantitative EEG (qEEG) with placebo in healthy humans. METHODS A randomized, double-blind, cross over study of 12 healthy male volunteers. Subjects orally received capsules with 255-285 mg St John's wort extract (900 micro g hypericin content), 25 mg amitriptyline and placebo three times daily for periods of 14 days each with at… CONTINUE READING

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