The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress.

@article{File1985TheEO,
  title={The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress.},
  author={S. E. File and Sharon Pellow},
  journal={Pharmacology, biochemistry, and behavior},
  year={1985},
  volume={23 5},
  pages={737-41}
}
PK 11195 (1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isoquinolinecarboxami de, a potent ligand for peripheral benzodiazepine binding sites, was unable to reverse the anxiogenic effects of Ro 5-4864 (chlorodiazepam) in the social interaction test or in the punished drinking test. However, at 90 mg/kg PK 11195 also reduced social interaction, indicating an anxiogenic effect. Both PK 11195 (30-120 mg/kg) and Ro 5-4864 (20-60 mg/kg) significantly increased the plasma corticosterone… CONTINUE READING

From This Paper

Topics from this paper.
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…