The effects of Ni2+ on ionic currents and tension generation in frog ventricular muscle

@article{Klitzner1983TheEO,
  title={The effects of Ni2+ on ionic currents and tension generation in frog ventricular muscle},
  author={Thomas S. Klitzner and Martin Morad},
  journal={Pfl{\"u}gers Archiv},
  year={1983},
  volume={398},
  pages={267-273}
}
The effect of Ni2+ on E-C coupling events of the frog ventricular muscle were studied using a single sucrose gap voltage clamp technique. The results showed that Ni2+ increased the overshoot potential and depressed and prolonged the plateau of the action potential. Ni2+ also increased the dependence of the overshoot potential on [Na]o from 18 to 58 mV per… CONTINUE READING