The effects of NSAID on the matrix of human articular cartilages

  title={The effects of NSAID on the matrix of human articular cartilages},
  author={John T. Dingle},
  journal={Zeitschrift f{\"u}r Rheumatologie},
The present paper presents data obtained over a 12 year period, on the matrix synthesis and turnover in some 650 arthritic and 180 non-arthritic (N) human cartilages using a standardised in vitro method. When the relative metabolic (synthetic/repair activity) of these human cartilages was compared, it was demonstrated that in osteoarthritis (OA) and rheumatoid arthritis (RA) cartilages synthetic activity was diminished by approximately 50% as compared with N cartilages. However, the turnover… CONTINUE READING


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