The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells.

@article{MacNee1991TheEO,
  title={The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells.},
  author={W. MacNee and M. M. Bridgeman and Mungo Marsden and Ellen M. Drost and S Lannan and Christena Selby and Ken Donaldson},
  journal={The American journal of medicine},
  year={1991},
  volume={91 3C},
  pages={60S-66S}
}
We studied the mechanism of the delay in neutrophil traffic in pulmonary microvasculature previously observed during cigarette smoking, the effect of cigarette smoke on lung phagocytes and epithelial cell function, and augmentation of the glutathione (GSH) antioxidant system using the thiol drug N-acetylcysteine. Using a micropore membrane system to mimic the dimensions of the average pulmonary capillary, we showed that cigarette smoke reduces cell deformability, increasing the difficulty… CONTINUE READING

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