The effects of L-DOPA on regional cerebral glucose utilization in rats with unilateral lesions of the substantia nigra.

@article{Trugman1986TheEO,
  title={The effects of L-DOPA on regional cerebral glucose utilization in rats with unilateral lesions of the substantia nigra.},
  author={Joel M. Trugman and G. Frederick Wooten},
  journal={Brain research},
  year={1986},
  volume={379 2},
  pages={264-74}
}
Using [14C]2-deoxyglucose autoradiography, we have studied the effects of systemically administered L-DOPA (10, 25 and 50 mg/kg s.c.) on regional cerebral glucose utilization (RCGU) in rats with unilateral substantia nigra lesions. In comparison with lesioned rats treated with saline, the lesioned-DOPA treated rats demonstrated contralateral turning and RCGU changes in both ipsilateral and contralateral brain regions. L-DOPA treatment markedly increased RCGU in the ipsilateral entopeduncular… CONTINUE READING
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