The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys

@article{Buccafusco2004TheEO,
  title={The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys},
  author={Jerry J. Buccafusco and Thomas Weiser and Karin Winter and Klaus Klinder and Alvin V. Terry},
  journal={Neuropharmacology},
  year={2004},
  volume={46},
  pages={10-22}
}

AMPA Receptor Modulation for Enhancing Plasticity and Treating Neuropathology

Evidence that the compounds are effective in animal models of psychiatric disorders associated with abnormal brainstem activity is in agreement with this hypothesis, and positive modulators increase the production of brain growth factors that promote plasticity and neuronal viability.

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

  • M. Black
  • Biology, Psychology
    Psychopharmacology
  • 2004
Preclinical work on positive AMPA modulators is reviewed to suggest that positive modulation of AMPA may offer numerous therapeutic avenues for central nervous system drug discovery.

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat

Data support the pro-cognitive activity reported for AMPA receptor positive modulators and suggest that these compounds may be of benefit in treating disorders characterised by cognitive deficits such as Alzheimer’s disease and schizophrenia.

The AMPA modulator S 18986 improves declarative and working memory performances in aged mice

The memory-enhancing properties of S 18986 are confirmed and, in line with emerging data on multiple AMPA modulators, the relevance of targeting AMPA receptors in the development of new memory enhancers is highlighted.

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA‐Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

S 18986, a new selective positive allosteric modulator of AMPA‐type glutamate receptors, increased induction and maintenance of LTP in the hippocampus as well as the expression of brain‐derived neurotrophic factor (BDNF) both in vitro and in vivo.

The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques

The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures.

Although dopamine D(3) receptor antagonists have been shown to enhance frontocortical cholinergic transmission and improve cognitive performance in rodents, data are limited and their effects have

Piracetam, an AMPAkine drug, facilitates memory consolidation in the day-old chick

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