The effects of Doppler broadening and detector resolution on the performance of three-stage Compton cameras.

@article{Mackin2013TheEO,
  title={The effects of Doppler broadening and detector resolution on the performance of three-stage Compton cameras.},
  author={Dennis S. Mackin and Jerimy C. Polf and Stephen Peterson and Sam Beddar},
  journal={Medical physics},
  year={2013},
  volume={40 1},
  pages={
          012402
        }
}
PURPOSE The authors investigated how the characteristics of the detectors used in a three-stage Compton camera (CC) affect the CC's ability to accurately measure the emission distribution and energy spectrum of prompt gammas (PG) emitted by nuclear de-excitations during proton therapy. The detector characteristics they studied included the material (high-purity germanium [HPGe] and cadmium zinc telluride [CZT]), Doppler broadening (DB), and resolution (lateral, depth, and energy). METHODS The… 
Use of a LYSO‐based Compton camera for prompt gamma range verification in proton therapy
TLDR
The feasibility of using various CC designs and event selection methods to improve the imaging of PG rays is demonstrated, and in designed two‐stage CCs, the thin LYSO‐based absorber can provide better predictions of the distal falloff positions than the thick one.
Monte Carlo evaluation of a LYSO-based Compton camera using two origin ensemble algorithms with resolution recovery.
TLDR
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TLDR
The results show that the image quality of the reconstructed characteristic PG emission is improved with the proposed method in contrast to the standard reconstruction method using events from only one characteristic PG emissions.
PSF reconstruction for Compton-based prompt gamma imaging.
TLDR
It is found that the LM-OSEM algorithm followed by a shift-variant Richardson-Lucy deconvolution could reconstruct images with quality visually similar to the LM -OSEM-SV-PSF-reconstructed images, while requiring shorter computation time.
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TLDR
The developed analytic simulator and 3D image generator can be utilized to determine the optimal geometrical parameters, such as the distances between detectors and detector size, thus affecting the imaging performance of the Compton camera prior to the development of a real system.
Potentialities of High-Resolution 3-D CZT Drift Strip Detectors for Prompt Gamma-Ray Measurements in BNCT
Recently, new high-resolution cadmium–zinc–telluride (CZT) drift strip detectors for room temperature gamma-ray spectroscopic imaging were developed by our group. The CZT detectors equipped with
3D prompt gamma imaging for proton beam range verification.
TLDR
3D PG imaging for proton range verification under clinical beam delivery conditions is possible with a single Compton camera, and shifts in the proton beam range as small as 2 mm could be detected for delivery of a 2 Gy spot.
Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification.
TLDR
PGI with a CC for in vivo range verification during proton treatment delivery is feasible, however, improvements in the prototype CC detection efficiency and reconstruction algorithms are necessary to make it a clinically viable PGI system.
Range verification of passively scattered proton beams based on prompt gamma time patterns.
TLDR
This paper validated the hadronic models used in TOPAS by comparing simulations and prompt gamma spectrometry measurements published in the literature and performed four-dimensional Monte Carlo simulations using TOPAS to show the validity and accuracy of the technique.
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