The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions.

Abstract

The secreted protein Dickkopf-1 (Dkk1) is an antagonist of canonical Wnt signaling, expressed during fracture healing. It is unclear how it is involved in the mechanical control of bone maintenance. We investigated the response to administration of a Dkk1 neutralizing antibody (Dkk1-ab) in metaphyseal bone under different loading conditions, with or without… (More)
DOI: 10.1016/j.bone.2011.02.008

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