The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.

@article{Samer2010TheEO,
  title={The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.},
  author={Caroline Flora Samer and Youssef Daali and Melanie Wagner and G{\'e}rard Hopfgartner and C B Eap and Michela C Rebsamen and Michel Florian Rossier and Dennis Hochstrasser and Pierre Dayer and Jules Alexandre Desmeules},
  journal={British journal of pharmacology},
  year={2010},
  volume={160 4},
  pages={907-18}
}
BACKGROUND AND PURPOSE There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 and 3A], due to genetic polymorphisms and/or drug-drug interactions. The effects of CYP2D6 and/or CYP3A activity modulation on the pharmacokinetics of oxycodone remains poorly explored. EXPERIMENTAL APPROACH A randomized crossover double-blind placebo-controlled study was performed with 10 healthy volunteers genotyped… CONTINUE READING

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