The effects of Aroclor 1254 on undifferentiated and NGF-stimulated differentiating PC12 cells.


Rat pheochromocytoma [PC12] cells were used as models of a dopaminergic system to examine the effects of subchronic exposure to Aroclor 1254 on levels of cellular dopamine in undifferentiated and nerve growth factor (NGF)-stimulated differentiating cells. Either in the absence, or simultaneously in the presence of NGF, exposure to Aroclor 1254 resulted in… (More)