The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation.

@article{MacFarlane1975TheEO,
  title={The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation.},
  author={Donald MacFarlane and david. c. mills},
  journal={Blood},
  year={1975},
  volume={46 3},
  pages={309-20}
}
The influence of freshly purified ATP on the effects of aggregating agents on human platelets was studied. ATP inhibited aggregation induced by ADP competitively (Ki = 20 muM) and immediately without need for prior incubation. ATP had no effect on primary aggregation induced by adrenaline, thrombin, vasopressin, or 5-hydroxytryptamine (5HT). ATP inhibited the shape change and the consumption of metabolic ATP induced by ADP but did not inhibit these effects when induced by thrombin, vasopressin… CONTINUE READING