The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo.

@article{TyeDin2010TheEO,
  title={The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo.},
  author={Jason A. Tye-Din and Robert P. Anderson and Rosemary A Ffrench and Gregor J E Brown and Peter Hodsman and Matthew Siegel and Wendy Botwick and Revati Shreeniwas},
  journal={Clinical immunology},
  year={2010},
  volume={134 3},
  pages={289-95}
}
Effective treatment of celiac disease is an unmet medical need. A glutenase that destroys immunogenic gluten peptides may be clinically valuable. Twenty patients with celiac disease were randomly assigned to ingest a large gluten meal (16 g daily for 3 days) pre-treated with ALV003, a mixture of highly specific glutenases (n=10), or pre-treated with placebo (n=10). Peripheral blood T-cell IFN-gamma ELISpot responses to gliadin and an immunogenic 33mer and symptoms were assessed. While baseline… CONTINUE READING

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