The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro.

Abstract

Electrical field stimulation of guinea pig tracheal strips and human bronchial rings, in vitro, evokes a cholinergic contraction mediated by the release of acetylcholine. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a 5-HT1A and 5-HT7 agonist. In this study, we have investigated whether 8-OH-DPAT could modulate the cholinergic contraction in guinea… (More)

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@article{Dupont1998TheEO, title={The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro.}, author={Lieven Joseph Dupont and J L Pype and Maurits G. Demedts and Paul R De Leyn and G J Deneffe and Geert M. Verleden}, journal={American journal of respiratory and critical care medicine}, year={1998}, volume={158 5 Pt 1}, pages={1479-86} }