The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina.


Perfusion of 100 microM 2-amino-4-phosphonobutyric acid (APB) into the in vivo rabbit eye-cup selectively and reversibly blocked the b-wave of the ERG and all On responses from retinal ganglion cells. In contrast, Off responses were occasionally enhanced, sometimes dramatically. The antagonistic surround inputs to Off ganglion cells, identified by their… (More)