The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo.

  title={The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo.},
  author={Q. He and X D Na},
  journal={Leukemia research},
  volume={25 6},
  • Q. He, X. Na
  • Published 1 June 2001
  • Biology, Chemistry, Medicine
  • Leukemia research
A. cantoniensis inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immunoresponses in vivo.
AC can affect WEHI-3 cells in vivo and promote macrophage and NK cell activities and it was found that the NK cells from mice after treatment with AC can kill the YAC-1 target cells.
Gallic acid inhibits murine leukemia WEHI-3 cells in vivo and promotes macrophage phagocytosis.
Gallic acid caused a significant decrease in the weights of the spleens and livers from BALB/c mice and promoted the activity of macrophage phagocytosis in the white blood cells from peripheral blood mononuclear cells (PBMCs) at 40 and 80 mg/kg treatment doses, but decreased the macrophages in isolated peritoneal cells at the 80mg/kg dose.
Therapeutic effects of sesamolin on leukemia induced by WEHI-3B in model mice
Results indicated that sesamolin exerts anti-leukemic effects in vivo, and induced a twofold increase in the cytotoxic activity of leukemic mouse NK cells against WEHI-3B cells.
Quercetin inhibited murine leukemia WEHI‐3 cells in vivo and promoted immune response
The purpose of the present studies was to focus on the in vivo effects of quercetin on leukemia WEHI‐3 cells, and it was found that an effect of quERCetin was observed in the spleen of mice previously injected with WEHI-3 cells.
Dunaliella salina exhibits an antileukemic immunity in a mouse model of WEHI-3 leukemia cells.
It is demonstrated that the application of D. salina had beneficial effects on WEHI-3 leukemic mice by prolonging survival via modulating the immune responses and reducing spleen enlargement in murine leukemia.
Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice.
Hedyotis diffusa Willd extract would appear to have antileukemia activity in WEHI-3 cell-induced leukemia in vivo.
Synthesis, NMR Characterization, and Antileukemic Activity of N-Nonanoylpiperazinyl-5α-Androstane-3α,17β-Diol A-Ring Derivatives
Assessment of their antiproliferative activity on leukemia HL-60 cells confirmed the best efficiency of the 2β-sidechain/3α-OH orientation (compound 1) compared to the other configurations tested (compounds 2–4).


Role of vitamin D3 receptor in the synergistic differentiation of WEHI-3B leukemia cells by vitamin D3 and retinoic acid.
Induction of VDR expression is a key component in the synergistic differentiation induced by 1,25-dihydroxyvitamin D3 and RA and RAR and not RXR must be activated for enhanced induction of the VDR and for the synergists differentiation produced by RA and 1, 25-(OH)2D3.
Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite
This work believes this to be the first demonstration of a sequential relationship between the application of an exogenous inducing agent, a reduction in myc mRNA levels and the development of characteristics associated with normal cell maturation.
Terminal erythroid differentiation in the K-562 cell line by 1-beta-D-arabinofuranosylcytosine: accompaniment by c-myc messenger RNA decrease.
The results suggest that ara-C treatment can irreversibly activate the erythroid differentiative program of K-562 cells.
[Synthesis of 2 beta-(4'-methyl-1'-piperazino)-3 alpha-hydroxyl-16,17- substituted-5 alpha-androstanes].
  • Q. He, Y. Xu
  • Chemistry, Biology
    Yao xue xue bao = Acta pharmaceutica Sinica
  • 1992
Preliminary results of biological experiment showed that the vicinal amino-alcohol compounds of 5 alpha-androstane possess to a different extent antiarrhythmic activities among which compounds VI, XI and XIV showed higher activities than others.
Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells.
The general characteristics of the actions of LIF, IL-6, and G-CSF suggested that each operates independently as a direct differentiation inducer of leukemic cells, and may be designed to exhibit coordinated biological functions in certain situations.
Development of neomycin-resistant WEHI-3B D+ murine cells as an in vivo model of acute nonlymphocytic leukemia.
Clone Y1 would appear to be an in vivo model of acute nonlymphocytic leukemia that may be useful for the development of therapeutic strategies to more successfully treat these diseases.
Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells
The observations suggest that the factor in post‐endotoxin serum most efficient in enforcing differentiation in myelomonocytic leukemic cells may be a subset of GM‐CSF molecules with a selective capacity to stimulate granulocyte colony formation by normal cells.