The effectiveness of treatments for androgenetic alopecia: A systematic review and meta‐analysis

@article{Adil2017TheEO,
  title={The effectiveness of treatments for androgenetic alopecia: A systematic review and meta‐analysis},
  author={Areej Adil and Marshall Godwin},
  journal={Journal of the American Academy of Dermatology},
  year={2017},
  volume={77},
  pages={136–141.e5}
}
  • A. Adil, M. Godwin
  • Published 1 July 2017
  • Medicine
  • Journal of the American Academy of Dermatology

Figures from this paper

Efficacy of non‐surgical treatments for androgenetic alopecia: a systematic review and network meta‐analysis
TLDR
Results of this NMA indicate the emergence of novel, non‐hormonal therapies as effective treatments for hair loss; however, the quality of evidence is generally low.
Systematic review of low-level laser therapy for adult androgenic alopecia
  • Sean W Delaney, Paul Zhang
  • Medicine
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
  • 2018
TLDR
Low-level laser therapy appears to be a promising noninvasive treatment for AA in adults that is safe for self-administration in the home setting and although shown to effectively stimulate hair growth when compared to sham devices, these results must be interpreted with caution.
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review
TLDR
Topical ketoconazole is a promising adjunctive or alternative therapy in the treatment of AGA and demonstrated clinical improvement of AGA based on photographic assessment and subjective evaluation.
Management of androgenetic alopecia: a review
TLDR
Drug-assisted delivery techniques have emerged to improve the efficiency of conventional drugs; transdermal drug delivery through ultrasound pressure waves means creating diffusion channels, increasing skin permeability and stimulating cell differentiation and growth factor utilization along with minoxidil absorption.
Safety and Efficacy of Mesotherapy in the Treatment of Androgenetic Alopecia: A Systematic Review
TLDR
Although the findings of previous studies suggest that mesotherapy is a safe and effective treatment for androgenetic alopecia, further research is needed to confirm this finding.
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TLDR
Treating androgenetic alopecia therapy remains challenging as treatment selection involves ethical, evidence-based decision-making and consideration of each individual patient's needs, compliance, budget, extent of hair loss, and aesthetic goals, independent of potential financial benefits to the practitioners.
Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis
TLDR
PRP is an autologous treatment that lacks serious adverse effects and effectively improves hair density and hair thickness in men and women with AGA.
Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature
TLDR
Most of the studies reviewed showed effectiveness of PRP in increasing terminal hair density/diameter in AGA, and additional investigations are needed to determine the optimal treatment regimen for high efficacy ofPRP in AGA.
Can we halt male androgenetic alopecia progression without antiandrogenic drugs?
TLDR
According to a recent meta-analysis of randomized controlled trials, finasteride, minoxidil, and low-level laser light therapy (LLLT) are the only treatments that have demonstrated efficacy for male-pattern hair loss, but it is likely that in the long term, these patients will experience a decrease in their hair counts below the baseline.
Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature
TLDR
Topical finasteride is a promising therapeutic option that aims to decrease complications caused by oral administration and is emphasize the importance of continued research for the establishment of a novel therapeutic agent.
...
...

References

SHOWING 1-10 OF 31 REFERENCES
Androgenetic alopecia in the female. Treatment with 2% topical minoxidil solution.
TLDR
Topical minoxidil was significantly more effective than placebo in the treatment of female androgenetic alopecia and the number of nonvellus hairs regrown was increased.
TREATMENT OF FEMALE ANDROGENETIC ALOPECIA WITH MINOXIDIL 2%
TLDR
The safety and efficacy of minoxidil 2% for the treatment of female androgenetic alopecia was assessed in a 32‐week double‐blind placebo‐controlled trial, with no serious side effects encountered during this study.
Low‐Level Light Therapy for Androgenetic Alopecia: A 24‐Week, Randomized, Double‐Blind, Sham Device–Controlled Multicenter Trial
TLDR
LLLT could be an effective treatment for AGA after 24 weeks of treatment, and the LLLT group showed significantly greater hair density than the sham device group.
Finasteride increases anagen hair in men with androgenetic alopecia
TLDR
Evidence is provided that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients and provides direct evidence thatfinasteride 1 mg daily promotes the conversion of hairs into the anagen phase.
Androgenetic alopecia: treatment results with topical minoxidil.
  • J. Roberts
  • Medicine
    Journal of the American Academy of Dermatology
  • 1987
Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients.
TLDR
It is found that scalp hair loss continued in a progressive manner over a 5-year period in placebo-treated men with AGA, with a loss of 239 hairs from baseline over the 5- year study period.
Finasteride in the treatment of men with frontal male pattern hair loss.
Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects
TLDR
Fifty-eight percent of the male population aged 30-50 years had AGA, and its grade increased with increase in age, and would benefit from hair transplantation while 44.1% had grades I to III and are potential candidates for medical treatment.
A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.
TLDR
Data from a patient questionnaire demonstrated that 5% topical minoxidil helped improve patients' psychosocial perceptions of hair loss in men with androgenetic alopecia as well as boosting hair regrowth in this 48-week trial.
...
...